The film begins with the child, Rizwan Khan (Tanay Chheda), a Muslim who has Asperger syndrome, growing up with his mother (Zarina Wahab) in the Borivali section of Mumbai.Later as an adult (Shahrukh Khan), Rizwan moves to San Francisco and lives with his brother and sister-in-law. While there, he falls in love with Mandira (Kajol). They eventually marry and begin a business.
After the events of 9/11, Rizwan and Mandira begin to face a number of difficulties. Following a tragedy, they separate. In order to win her back, Rizwan embarks on a long journey across the United States.
